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发布时间 ：2023-08-30 16:46 咨询量：
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产品详情
| 名称 ： | anti- TP53 antibody |
|---|---|
| 货号： | FNab08878 |
| 适应种属： | 人源,大鼠,小鼠 |
| 规格： | 100ug(微克) |
| 状态 ： | 液体 |
| 纯化方法 ： | 免疫亲和纯化 |
| 纯度： | 经SDS-PAGE分析,纯度大于95% |
| 宿主： | 兔 |
| 亚型： | lgG |
| 存储： | 用添加了0.02%叠氮化钠和50%甘油的PBS溶解,PH值7.3,可在-20℃下保存12个月（避免反复冻融） |
| 免疫原： | tumor protein p53 |
| 免疫原别称： | Cellular tumor antigen p53 antibody, FLJ92943 antibody, LFS1 antibody, P53 antibody, Phosphoprotein p53 antibody, TP53 antibody, TRP53 antibody, tumor protein p53 antibody, Tumor suppressor p53 antibody |
| 分子量： | 53 kDa |
| 验证应用： | ELISA, IHC, IP, WB, IF |
| 建议稀释比例： | WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:20-1:200 |
| UniProt ID： | P04637 |
| 克隆性： | 多克隆 |
| 背景介绍 ： | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21(lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK c |
| 图像： |  Immunohistochemistry of paraffin-embedded human ovary tumor tissue using FNab08878(P53 antibody) at dilution of 1:100。
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